Announcements

OSGA Webinar #26

Genome-wide Association Study Summary Statistics - Where to find them and how to use them

4/22/22 10am PDT/1pm EDT

Free Registeration Here
Summary of this webinar:
This presentation will guide attendees with how to access genome-wide association study summary statistics and showcase resources available for annotating these summary data for follow-up analyses, including gene-based analyses, eQTL, and epigenetic annotation as well as causal variable analysis. We will guide attendees through components of a GWAS summary dataset and two excellent resources - FUMA and MASSIVE - that use these summary files as inputs to generate vast amounts of annotations that can be brought forward to answer translational research questions.

Presented by:
Dr. Arpana Agrawal and Dr. Alexander S. Hatoum
Department of Psychiatry
Washington University School of Medicine

Series Information and Previously Recorded Webinars

OSGA Webinar #25

Mouse Phenome Database: Resources and analysis tools for curated and integrated primary mouse phenotype and genotype data

4/8/22 10am PDT/1pm EDT

View Here
Summary of this webinar:
The Mouse Phenome Database (MPD; https://phenome.jax.org) is a widely used resource that provides access to primary experimental data, protocols, and analysis tools for mouse phenotyping studies. Data are contributed by investigators around the world and represent a broad scope of phenotyping endpoints and disease-related characteristics in naïve mice and those exposed to drugs, environmental agents, or other treatments. MPD is engineered to facilitate interactive data exploration and quantitative analysis. It encompasses data from inbred strains and other reproducible panels, including HMDP, KOMP, Collaborative Cross (CC), CC-RIX, and founder strains, along with primary data from mapping populations, including historic mapping crosses and advanced high-diversity mouse populations such as Diversity Outbred mice. A new Study Intake Platform (SIP) for data contributors allows domain experts to submit and annotate their own data with relevant ontology terms. Data contributors also provide detailed information for protocols and animal environmental conditions to fulfill ARRIVE guidelines. Data are exposed to analysis tools within MPD and are available through APIs to other systems. We will demonstrate selected MPD tools, including GenomeMUSter (a new imputed SNP grid on 500+ strains of mice, 83+M locations) and a GWAS metanalysis tool.

Presented by:
Molly Bogue and Robyn Ball
With other senior members of the MPD team: Elissa Chesler, Vivek Philip, Dave Walton
The Jackson Laboratory

Series Information and Previously Recorded Webinars

eQTLs for HRDP v5

11/1/21 - Brain/Liver/Kidney eQTLs using the full panel of HRDP animals available 43 strains have now been calculated with GEMMA and are available now.

OSGA Webinar #23

Julia: a fast, friendly, and powerful language for data science

11/12/21 10am PDT/1pm EDT

View Here
Summary of this webinar:
Julia is a high-level dynamic programming language that is gaining popularity. The Julia language is designed for scientific computing and offers several attractive features for data science applications. In this webinar, we will make a case for why a data scientist might consider taking a serious look at Julia. We will show code examples and point the audience to further resources.


Gregory Farage, PhD
Post-Doctoral Fellow
Department of Preventive Medicine
University of Tennessee Health Science Center

Saunak Sen, PhD
Professor and Division Chief
Department of Preventive Medicine
University of Tennessee Health Science Center

Series Information and Previously Recorded Webinars

Kidney RNA-Seq

9/7/21 - Kidney transcriptome and HXB/BXH expression values and eQTLs are avaialble in the genome browser. WGCNA results will be available soon.

OSGA Webinar #22

Guide to evaluating the application of machine learning methods in genetics literature

10/22/21 10am PDT/1pm EDT

View Here

Summary of this webinar:



Laura Saba, PhD
Associate Professor
Department of Pharmaceutical Sciences
University of Colorado Anschutz Medical Campus

Series Information and Previously Recorded Webinars

PhenoGen update 3.7.5

12/11/20 update to v3.7.5

PhenoGen update 3.7.4

11/18/20 update to v3.7.4

PhenoGen v3.7.3

PhenoGen v3.7.2

PhenoGen v3.7.1

PhenoGen v3.7

PhenoGen v3.6

Rat Genomics Workshop 8/2-8/3

Look for another workshop spring/summer 2020

Summer of Rat Genomics and Genetics Workshop - Aug 2nd-3rd, 2019 - Colorado - NIDA Center for Omics, Systems Genetics and the Addictome
Come to Colorado in August for a 2-day hands-on workshop on web-based tools for rat genetics/genomics including RGD, GeneNetwork2, PhenoGen, GeneWeaver, and several others. Offered by the NIDA Center for Omics, Systems Genetics, and the Addictiome.
More Info
Registration

Complex Traits Consortium 2019

PDFs of posters for CTC 2019 Meeting:
Circular RNA Array/Predictions
PhenoGen REST API - gene level data

Phenogen in the Cloud

This is the new home for PhenoGen running in the cloud. As such, a large number of changes have occurred in the background that will help us maintain the site and improve performance. Please excuse some ongoing bugs as we are beta testing the site now. This is not currently the recommended version. However, we would appreciate any help testing the supported features by simply using this site as you would the previous site.

REST API Survey 2/20/2018

Please help us prioritize effort on a REST API to provide access to data on Phenogen. Take the 1 question survey below.

PhenoGen v3.4.2 3/9/2018

Added read depth count tracks to the genome browser for whole brain and liver for the inbred strains: ACI, Dark-Agouti, Cop, F344-NCl, F344-NHsd, LEW-Crl, LEW-SsNHsd, SHRSP, SR-JrHsd, SS-JrHsd, and WKY.

PhenoGen v3.4.1 2/16/2018

The Genome/Transcriptome Data Browser can now look up genes by either their gene or transcript PhenoGen ID.

NIDA Genetics Consortium Meeting Poster

NIDA Meeting Poster - Download the poster from the NIDA meeting with an outline of ways to use our WGCNA Modules and recent examples of our use with phenotype QTLs. Download here.

PhenoGen v3.4 12/10/2017

Recombinant Inbred Small RNA - Added expression data for small RNA features across RI Panel in Whole Brain and Liver.

PhenoGen v3.3 4/30/2017

Recombinant Inbred Total RNA - Added expression data for reconstructed transcripts across RI Panel in Whole Brain and Liver. Added RNA-Seq based WGCNA for Whole Brain and Liver.

PhenoGen v3.2 11/13/2016

Small RNA - added tracks and detail on all known and novel (predicted by MiRDeep and SNOSeeker) small RNAs in Brain, Heart, and Liver from the BNLx/SHR parental strains.
Merged Total RNA Transcriptome - added a track with the merged transcriptome from the 3 available tissues and assigned new unique PhenoGen IDs to all novel transcripts.

PhenoGen v3.1 6/15/2016

Rn6 - is available in the browser, for gene list analysis, and both RNA-Seq datasets and microarray datasets have been updated.
Rat WGCNA - Heart and Liver have been added to the rn6 data.

PhenoGen v3.0 5/31/2016

Anonymous Gene List - You can now use our gene list analysis tools without registering. We encourage you to link your email so you don't loose access to previous work.
Rn6 (June 2016): Rn6 - Will be available in June 2016. Rn6 and Rn5 will be available in the genome browser, public HXB datasets, and gene list analysis tools.

PhenoGen v2.16.1 11/10/2015

Security Updates - We now require using HTTPS so all of the data transmitted between your browser and our server is encrypted. Update your bookmarks.
Future Update: Rn6 - We are still working on updating the Microarrays and RNA-Seq data to Rn6. Our next major update will include Rn6.

PhenoGen v2.16 7/21/2015

Minor Updates 6/8/2015

We've made a couple of minor updates since the last release.

Workshop Video/Slides 4/16/2015

Watch the workshop:


OR
Download the slides from the Informatics Workshop here.

v2.15 of PhenoGen 3/7/2015


We've added GO term summary and miRNA targeting views to the Weighted Gene Co-expression Network Analysis. Look at what's new for a summary of changes.

HTTPS support 2/9/2015

We now support https to keep your connections more secure. We will eventually redirect all traffic to the secure site, but for now feel free to try it out here: https://phenogen.ucdenver.edu/PhenoGen/

v2.14 of PhenoGen 1/10/2015


We've added Weighted Gene Co-expression Network Analysis. Look at what's new for a summary of changes.

v2.13 of PhenoGen 9/27/2014

We've updated PhenoGen. Look at what's new for a summary of changes.

Added multiMiR


Using multiMiR(an R package available here) you can view validated and predicted miRNAs that target specific genes. You can also select a miRNA and view all genes targeted by the miRNA. multiMiR is avaialble as a new tab for a selected gene in the Genome/Transcriptome Data Browser and in Gene Lists after selecting a list. It is currently available only for mouse genes, but will be available in rat soon.

Added Rat Liver Transcriptome

We've added rat liver tracks including, a transcriptome reconstructiong track, splice junction track, and stranded read depth count tracks. Available in the Genome/Transcriptome Browser.

Follow on Facebook/Google+/Twitter

Follow PhenoGen to keep up with new features, demonstrations, and help by providing feedback to direct future updates.


RNA-Seq Data Summary Graphics

Rat Brain RNA-Seq data summary graphics are now available. Click below to browse the RNA-Seq data summary:

Reconstructed transcripts from this RNA-Seq data are still combined with PhenoGen array data in Genome/Transcriptome Data Browser.